Abstract: OBJECTIVE To observe the effect of modified Jinkui Shenqi pills, on the thymus and activation regulated chemokine(TARC) and eosinophile(EOS) count in rats with asthmatic. METHODS Sixty rats were randomly divided into 6 groups: the normal group, the model group, the dexamethasone group, the modified low, medium and high dose groups. The chronic asthmatic model was established by repeated inhalation of ovalbumin. The morphological change of bronchial and lung tissues, the number of EOS in bronchoalveolar lavage fluid and the content of lung tissue TARC were observed. RESULTS Jinkui Shenqi pills obviously improved the asthma degree, decreased the content of TARC and EOS(P<0.05 or P<0.01). Pathological results revealed that the bronchial mucosa epithelial cells and goblet cells hyperplasia, alveolar contains secretions and inflammatory cells infiltration, luminal stenosis in the model group. And these changes were released obviously in the modified Jinkui Shenqi pills groups. CONCLUSION Modified Jinkui Shenqi pills can treat asthma possibly by inhibiting TARC and EOS.