Abstract: OBJECTIVE To study the effection of dihydromyricetin from Cany Tea on acute gouty arthritis model joint swelling degree and rats serum of IL-1β, IL-8, TNF-α, and to explore the action mechanism of the acute gouty arthritis treatment. METHODS Establish rats model of acute gouty arthritis by using the ankle articular injection of sodium urate, the control group use the colchicine and observe the regulation of dihydromyricetin from Cany Tea on rats ankle swelling and serum levels of TNF-α, IL-1β, and IL-8 in each group. RESULTS The degree of joint swelling and IL-1β, IL-8, and TNF-α levels of model group were significantly higher than the normal group(P<0.05, P<0.01); High and middle dose of dihydromyricetin from Cany Tea could significantly inhibit acute gouty arthritis in rats ankle swelling and reduce serum TNF-α, IL-1βand IL-8 level. CONCLUSION Dihydromyricetin from Cany Tea has a good role in the prevention and treatment of acute gouty arthritis, its mechanism of action is the inhibition of serum IL-1β, IL-8 and TNF-α production.