Abstract: Calcitonin gene related peptide(Calcitonin gene-related peptide, CGRP) is currently known as the strongest endogenous active peptide of diastolic blood vessels in the body. In recent years, CGRP has become a hot research topic in the field of treating migraine at home and abroad. A large number of literature shows that the trigeminal vascular system(TGVS) plays an important role in migraine. Even some researchers pointed that inhibiting the release of CGRP and the activity of CGRP receptor is the key point of migraine treatment. In order to clarify the role of CGRP in migraine attac and to provide theoretical support for existing drugs and developing new migraine drug treatment, the paper reviews the domestic and foreign literature about CGRP and mechanism of migraine trigeminal vascular system.