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    黄杞叶黄酮类成分的研究

    Studies on Flavonoids from the Leaves of Engelhardia Roxburghiana

      摘要
    • 摘要: 目的 研究黄杞叶中的黄酮类成分。方法 综合采用硅胶、Sephadex LH-20柱色谱及制备型高效液相色谱法，对黄杞叶中的黄酮类成分进行分离纯化，根据理化性质并结合UV、HPLC/Q-TOF-ESI-MS、1H-NMR、13C-NMR、DEPT、HMBC数据及文献进行结构鉴定。结果 分得了6个化合物，分别鉴定为落新妇苷(化合物Ⅰ)、黄杞苷(化合物Ⅱ)、槲皮苷(化合物Ⅲ)、(2R, 3R)5, 7, 3', 4'-四羟基二氢黄酮-3-氧-α-L-鼠李糖(3→1)-β-D-葡萄糖苷(化合物Ⅳ)、(2R, 3R)5, 7, 4'-三羟基二氢黄酮-3-氧-α-L-鼠李糖(3→1)-β-D-葡萄糖苷(化合物Ⅴ)、(2R, 3R)-5, 7, 4', 5'-四羟基二氢黄酮-3-氧-(3"-氧-没食子酰基)-α-L-鼠李糖苷(化合物Ⅵ)。结论 化合物Ⅴ为首次从该植物中得到，也是新化合物。

       

      Abstract: OBJECTIVE To study the flavonoids from the leaves of Engelhardia roxburghiana for better using the traditional Chinese medicine. METHODS The flavonoids was isolated and purified by silica gel, Sephadex LH-20 column chromatography, preparative HPLC and the structures were elucidated on the basis of spectral data including UV, HPLC/Q-TOF-ESI-MS, 1H-NMR, 13C-NMR, DEPT, HMBC and physiochemical properties. RESULTS Six flavonoids were obtained from the 95% ethanol extract and their structures were identified as astilbin (Ⅰ), engelitin (Ⅱ), quercitrin (Ⅲ), (2R, 3R)5,7,3’,4’-tetrahydroxyflavanonol-3-O-α-L-rhamnopyranosyl(3→1)-β-D-glucopyranoside (Ⅳ), (2R, 3R) 5, 7, 4'-trihydroxyfla- vanonol-3-O-α-L-rhamnopyranosyl (3→1)-β-D-glucopyranoside (Ⅴ), (2R, 3R)-5, 7, 4', 5'- tetrahydroxyflavanonol-3-O-(3"-O- galloyl)-α-L-rhamnopyranoside (Ⅵ), respectively. CONCLUSION Compound Ⅴ is first isolated from the title plant and reported for the first time.

       

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