Abstract: OBJECTIVE To study the effect of zoledronic combined salcatonin on postmenopausal osteoporosis fractures. METHODS Sixty postmenopausal women of osteoporotic spinal compression fractures were randomly divided into control group and observation group. All the patients were treated by calcium supplement with vitamin D chewable tablets and salcatonin injection. The patients of observation group were intravenously injected zoledronic injection on the basis of before. The bone mineral density(BMD) of lumbar vertebra was measured after 6 months compared to before the treatment. The visual simulation score(VAS) and Oswestry disability index (ODI) was used to assess patients pain relief and dysfunction improvement. RESULTS After treatment of 6 months, the increase of BMD , the decrease of VAS and ODI was significant compared with before the treatment(P<0.01). The increase of BMD and the decrease of ODI in observation group was significant compared with control group (P<0.05). CONCLUSION The study reveales an increase in BMD, relief from pain and improvement quality of life follwing the treatment of zoledronic combined salcatonin in postmenopausal osteoporosis fractures.