GC-ECD测定聚偏二氯乙烯类药品包装材料中偏二氯乙烯单体含量

Determination of Ethylene Dichloride in Drug Packaging Material of Polyethylene Dichloride by Headspace GC-ECD

摘要: 目的建立聚偏二氯乙烯类药品包装材料中偏二氯乙烯单体含量的顶空气相色谱-电子捕获检测器(GC-ECD)法。方法采用HP-INNOWax (30.0 m×320 μm，0.25 μm)色谱柱；ECD检测器；顶空平衡温度为80 ℃，平衡时间为30 min，柱温为50 ℃，进样口温度为200 ℃，检测器温度为300 ℃，电流为1 nA；氦气载气，柱流速为1.0 mL·min^-1。结果在2.0~150.0 ng内呈线性关系(r=0.999 2)；平均回收率为99.1%，RSD=0.6%。结论顶空GC-ECD可以准确、灵敏地测定聚偏二氯乙烯类药品包装材料中偏二氯乙烯单体的含量。

Abstract: OBJECTIVE To develop a method for determination of ethylene dichloride in drug packaging material of polyethylene dichloride by headspace GC-ECD. METHODS An HP-INNOWax(30.0 m×320 μm, 0.25 μm) capillary column and ECD detector was adopted. The headspace equivilent temperature was 80 ℃ for 30 min, the oven temperature was 50 ℃, inlet temperature was 200 ℃ and detector temperature was 300 ℃, the current was 1 nA. He was used as carrier gas. The flow rate was 1.0 mL·min-1. RESULTS The method had a linear range in 2.0-150.0 ng (r=0.999 2). The average recovery was 99.1%, RSD=0.6%. CONCLUSION The headspace GC-ECD method is accurate, sensitive to determine ethylene dichloride in drug packaging material of polyethylene dichloride.