Abstract: OBJECTIVE To evaluate the efficacy and safety of Sofren injection for angina pectoris. METHODS performed a computer retrieval for Medline, Embase, The Cochrane Library, CNKI, Vip and Wanfang Data. included randomized controlled trials which accorded to the inclusion and exclusion criterial and evaluated the quality of those literature and conducted a meta-analysis for them. RESULTS Fourteen literatures and 1 616 patients were included. The combined OR of angina symptoms and ECG efficacy of 2 groups were equaled to 2.29 and 2.16, and 95% confidence interval (CI values) were (1.78, 2.96) and (1.69, 2.76). Meta-analysis showed that Sofren injection was effective in the treatment of angina pectoris to improve the angina symptoms and ECG efficacy. But no reliable evidence verified its safety. CONCLUSION A little evidence shows that Sofren injection is superior to simple basic therapy in the symptoms and ECG improvements as an auxiliary drug. However, this systematic review can not draw a conclusion about the effectiveness of Sofren injection in the treatment of angina pectoris because of the poor quantity included trials and lack of important indicators and related indicators of quality of life.