Abstract: OBJECTIVE To perform the special prescription evaluation about the use of vancomycin in orthopedics department, to promote its rational clinical application. METHODS Obtaining the medical records of orthopaedic inpatients with vancomycin from 2011 to 2013, and evaluating of the rationality in the five following aspects: indication of vancomycin,usage and dosage, treatment course, curative effect and etiology examination. RESULTS There was no abuse of vancomycin in orthopedics department, physicians value the etiology examination. But individual records existed that drug choice or treatment course was not reasonable and solution diluted concentration was too high, physicians acquainted incompletely themself with etiology examination, and so on. CONCLUSION Carrying out the special prescription evaluation, the pattern benefits correcting existing problems in clinical use, and standardizes the rational use of drug.