Abstract: OBJECTIVE To understand the calcium channel blockers in clinical application and precautions for pharmacists to provide a theoretical support for clinical drug monitoring by reviewing calcium channel blockers in clinical application and adverse reactions of the system. METHODS The literature of the way, the systematic study of clinical applications and adverse reactions calcium channel blockers were reviewed. RESULTS Calcium channel blockers were widely used in cardiovascular and other diseases, adverse reactions included arrhythmia, hypotension, atrioventricular block, heart failure, gingival hyperplasia, peripheral edema, constipation. Its common and rare adverse reactions should be focused to promote rational drug use. CONCLUSION The use of a class of drugs in the process, not only to focus on the pharmacological effects of drugs and clinical efficacy, better before using foresaw adverse drug reactions, in order to achieve prevention and treatment, the efficacy of the biggest play of the drug.