Abstract: OBJECTIVE To investigate the influence of copovidone on dissolution improvement of crospovidone, METHODS Cefuroxime axetil, albendazole and indomethacin were adopted as model drugs.To determine the dissolution of the drugs to explore the influence of copovidone. RESULTS Dissolution of cefuroxime axetil and albendazole could be enhanced by the addition of copovidone without changing the usage level of crospovidone, even under the condition of decreasing the concentration of crospovidone, but there was no effect on the dissolution of indomethacin. CONCLUSION Copovidone can significantly enhance the dissolution improvement effect of crospovidone on some poorly water soluble drugs.