Abstract:
OBJECTIVE To observe the mechanism of Bushen medicine improving ovarian reserve and endometrial receptivity in vitro fertilization-embryo transplantation cycle by Meta-analysis, to provide objective evidence for clinical treatment. METHODS The clinical randomized controlled researches that the Bushen medicine improve ovarian reserve and endometrial receptivity in IVF-ET cycle were searched from the China National Knowledge Infrastructure (2000?2014) and Wanfang(2000?2014) database. The qualified researches were filtrated according to inclusion criteria and exclusion criteria. The Meta-analysis was performed by RevMan 5.2 statistical software (counting data using Odds Ratio(Odds thewire, OR), measurement data using Mean Diffence). Finally, analyzing the 95% confidence interval and the forest figure. RESULTS Twelve literatures were included in this meta-analysis(795 cases ). Patients voluntarily accepted the treatment of Bushen medicine and the IVF treatment. The datas were analyzed, include the number of oocytes, estrogen level on the HCG injection day, fertilization rate, high quality embryo rate, endometrial thickness, uterine blood pulsing index and resistance index of uterine blood, clinical pregnancy rate. The result shows that the experimental group (Bushen medicine and western medicine) is better than the control group (western medicine group) in improving ovarian reserve and endometrial receptivity in IVF-ET cycle. CONCLUSION Compared with the western medicine, Bushen medicine treatment is more advantageous in improving ovarian reserve and endometrial receptivity, therefore, Buhsen medicine can improve the clinical pregnancy rate of IVF patients. Of which 10 articles were assessed as 3 score on Jadad Scale, so it is limited to support this conclusion, it is looking forward to have more high quality clinical randomized controlled trials to confirm the findings.