Abstract: OBJECTIVE To explore one case of clinical pharmaceutical care of patient suffered from obstructive jaundice caused by liver damage induced by rosuvastatin calcium combined with valsartan capsule. METHODS The process of clinical pharmacist participating in treatment process for coronary atherosclerotic cardiopathy was introduced, from the perspective of pharmacology, the liver damage leaded by statins and related to pharmacological dose, pharmacokinetics and other statin-induced interactions. Pharmacist provided related recommendations. RESULTS Physicians only considered the liver damage leaded by statins. thinking of the interaction with rosuvastatin calcium and valsartan, clinical pharmacist recommended that valsartan also should be withdrawn. CONCLUSION the cooperation of doctors and pharmacists can improve rationaldrug use, and ensure the medication safety. Simultaneously, the cooperation provides the clinical pharmacists a new way of thinking about the implementation of pharmaceutical care.