灯盏花素微乳凝胶剂的体外释放度考察

In Vitro Release Investigation of Breviscapine Microemulsion-based Gel

摘要: 目的考察灯盏花素微乳凝胶剂体外释放度。方法以pH 6.8的磷酸盐缓冲溶液为释放介质，分别采用正向透析扩散法和反向透析扩散法进行药物体外释放度试验。结果采用反向透析扩散法测得的药物释放速率显著高于正向透析扩散法，采用反向透析扩散法时灯盏花素微乳凝胶剂在2 h内的累积释放量>60%，10 h的累积释放量>90%，其体外释药符合一级动力学方程。结论采用反向透析扩散法方便快捷，能较好地模拟灯盏花素微乳凝胶剂的释药行为，灯盏花素微乳凝胶剂体外释药性能良好。

Abstract: OBJECTIVE To investigate in vitro release of breviscapine microemulsion-based gel. METHODS The positive and reverse dialysis bag techniques were performed to measure the in vitro release of breviscapine microemulsion gel, PBS(pH 6.8) was the release medium. RESULTS Breviscapine was released more rapidly by reverse dialysis bag technique than the positive one. The reverse dialysis bag technique showed that it released above 60% within 2 h, beyond that, it released above 90% at 10 h. The optimal process fitting one-order kinetic mechanism. CONCLUSION The reverse dialysis bag technique could preferably simulate the release behavior of breviscapine microemulsion gel. The characteristic of in vitro release of breviscapine microemulsion-based gel is good.