Abstract: OBJECTIVE To observe the effect of recombinant human brain natriuretic peptide(rhBNP) combined with low dose furosemide in the acute myocardial infarction complicating heart failure therapy. METHODS 50 cases of patients of acute myocardial infarction with heart failure were randomly divided into rhBNP treatment group (24 cases) and control group (26 cases). RhBNP treatment group were given rhBNP(0.5 mg) loading dose 1.5 μg·kg^-1 within 3-5 min based on the control group treatment, and then intravenously given at a speed of 0.01 μg·min^-1·kg^-1 within 72 h continuously, control group were given 40 mg furosemide intravenously, etiologies and vasodilator therapy and other symptomatic treatment every day. Observed the cardiac function index, serum brain natriuretic peptide(BNP), hypersensitive c-reactive protein(hs-CRP) concentration changes of the two groups before and after treatment. RESULTS Both two groups before and after treatment the left ventricular end diastolic diameter (LVDd) had no significant changes, and the LVEF in rhBNP treatment group obviously increased(P<0.05), the two groups’ plasma BNP, hs-CRP serum levels decreased(P<0.05), and the rhBNP treatment group improved better than the control group(P<0.05). CONCLUSION The effect of rhBNP combined with little dose furosemide treatment is obviously better than furosemide general treatment, which can effectively improve the symptoms of patients with acute myocardial infarction complicated with heart failure, and can also reduce diuretic resistance.