Abstract: OBJECTIVE To compare the pharmacokinetics between glycyrrhizic acid phospholipid complex self emulsifying preparation(T) and glycyrrhizic acid diammonium enteric coated capsule(R) in dogs. METHODS Six Beagle dogs were given orally T and R, with a single dose of 50 mg·kg^-1 glycyrrhizic acid in self crossover study. The plasma concentration of glycyrrhizic acid was assayed by HPLC and the pharmacokinetic parameters were calculated with DAS2.0 program. RESULTS T_max for R and T were (6.00±0.000)h and (2.917±0.585)h; C_max for R and T were (12.756±1.075)mg·L^-1 and (17.751±1.604)mg·L^-1, respectively; AUC_0-t were (150.894±22.850)mg·h·L^-1 and (211.196±40.880)mg·h·L^-1; AUC_0-∞ were (159.39±21.862)mg·h·L^-1 and (221.287±42.164)mg·h·L^-1; the relative bioavailability of T was 139.76%. CONCLUSIONS The pharmacokinetics of glycyrrhizic acid in dogs accorded with the two compartment models and with the first-order absorption after T or R administration orally, C_max, AUC_0-t and AUC_0-∞ of T were all higher than those of R, and T had a higher bioavailability, which reached the object of this task.