Abstract: OBJECTIVE To discuss the way to select drug for anti-infective treatment of paediatric patient with methicillin-resistant stphylococcus aureus(MRSA) infection in acute osteomyelitis and the pharmaceutical care provided by clinical pharmacists. METHODS The process of clinical pharmacist participating in anti-infective treatment for a paediatric patient with acute osteomyelitis was introduced. Clinical pharmacist designed individual medication scheme by considering about selection of anti-infective drug, drug dosage, route of administration and adverse drug reaction, and pharmaceutical care was conducted. RESULTS & CONCLUSION Cooperation of clinical pharmacist, physicians and nurse can improve rational drug use and drug therapy, and ensure the medication safety.