Abstract: OBJECTIVE To review the research progress on the resistant mechanisms of tigecycline-resistant bacterias in clinic. METHODS Base on the correlative reports in recent years, the resistant mechanisms of tigecycline-resistant bacterias were illustrated respectively. Also, the epidemiology of tigecycline-resistant bacterias were analyzed subsequently. RESULTS The resistant mechanisms of tigecycline-resistant bacterias mainly involved the efflux pump system and alteration of the drug targets, as well as the occurrence of resistant enzymes. The RND efflux pump plays a key role in the efflux pump system. Tigecycline-resistant bacterias has become a tough problem in clinical anti-infection therapy. CONCLUSION The definite mechanism of tigecycline resistant remains elusive. Further study are needed so as to guide rational use of tigecycline in clinic.