Abstract: OBJECTIVE To extract naringin from pomelo with hot water and enriched by macroporous resin, and then observe its function. METHODS The adsorption and elution performances of various macroporous resins were screened using the adsorption rate and desorption rate as indexes. RESULTS HPD450 had the best adsorption effect. The optimal adsorption conditions were 2 BV·h^-1 of upflow rate and 2.36 mg·mL^-1 of concentration as well as the optimal desorption conditions were 50% of ethanol concentration, 4 BV of dosage and 3 BV·h^-1 of flow rate. The preliminary function study indicated that naringin had a sound anti-oxidation performance at a concentration of 3.75 mg·mL^-1. In addition, the mice presented less sleep latencies and moved relative slowly at a dosage of 20 mg·kg^-1 of naringin. CONCLUSION HPD450 has the good adsorption edffect, suggesting that naringin has good sedative and hypnotic effects.