Abstract: OBJECTIVE To improve the dissolution determination method of captopril tablets. METHODS The new established dissolution determination method was the basket method. The 0.01 mol·L^-1 hydrochloric acid of 900 mL was used as the dissolution medium, the rotation speed was 50 r·min^-1 and the time was 20 minutes. RESULTS According to the USP dissolution test on sample of manufacturer A and B, the difference of dissolution curves was obvious. In addition, the sample of manufacturer B was unqualified and the uniformity of within-lot was bad. CONCLUSION The improved method inhibites the degradation of captopril. It provides a reference for the quality control of captopril tablets, and can be used for the dissolution test of captopril tablets.