Abstract: OBJECTIVE To provide reference for clinical pharmacists discovering and participating in pharmaceutical care for warfarin resistance patients. METHODS Based on gene detection, the anticoagulation plan was built and the reason inducing warfarin resistance was analyzed. The process of pharmaceutical care by clinical pharmacist was described in details. RESULTS INR of the patient achieved the target area and hemorrhage events were avoided post-discharge. CONCLUSION For warfarin resistance patients, clinical pharmacists particularly need to discover in time and keep long term follow-up and pharmaceutical care.