Abstract: OBJECTIVE To evaluate the effects of dexmedetomidine combined with lidocaine mucilage on extubation response in patients receiving double lumen endotracheal intubation. METHODS One hundred ASA Ⅰ or Ⅱ patients scheduled for pulmonary lobectomy under general anesthesia were randomly divided into 4 groups(n=25 each): control group, dexmedetomidine group, lidocaine mucilage group and combine treatment group(dexmedetomidine combined with lidocaine mucilage). The plasma epinephrine and norepinephrine level were detected and MBP and HR were recorded immediately before iv infusion of dexmedetomidine(T₀), immediately before extubation of DLT(T₁), at 5 min after extubation(T₂), at 10 min after extubation(T₃). The severity of cough was assessed. RESULTS The level of plasma epinephrine and norepinephrine in four groups, MAP and HR in control group, dexmedetomidine group and lidocaine mucilage group were significantly increased at T₁ than at T₀, all indexes in control group were significantly increased at T₂, T₃ than at T₀(P<0.05). Compared with control group, all indexes at T₁, T₂, T₃ and severity of cough during extubation in dexmedetomidine group, lidocaine mucilage group and combine treatment group were significantly decreased (P<0.05). Compared with combine treatment group, all indexes at T₁ and severity of cough during extubation in dexmedetomidine group and lidocaine mucilage group were significantly increased (P<0.05). CONCLUSION Dexmedetomidine combined with lidocaine mucilage can alleviate the response of extubation in patients receiving double lumen endotracheal intubation.