Abstract: OBJECTIVE To study the effect of different extracts of Xianti Jiangzhi Ⅰprescription on ovariectomized rats. METHODS All of 100 female SD rats, weighted about 270 g, were divided randomly into 10 groups, ten rats each group. The administration of drugs started 10 days after operation and continued for 13 weeks. In the end, the blood, fact were collected to make the following tests: serum lipids(TC, HDL-C, LDL-C), wet weight of abdominal fat, et al. RESULTS Every parts can signifycantly control the weight gain of the model rats(P<0.01). The part extracted by petroleum ether could control the food intake, lower the content of wet abdominal fat, reduce the lees indexes(P<0.05 or P<0.01), significantly lower the level of serum TC and LDL-C(P<0.01).CONCLUSION Every parts can significantly control the weight gain of the model rats. The part extracted by petroleum ether can control the food intake, improve lipid metabolism disorders, it may be the main efficacy part of Xianti Jiangzhi ⅠPrescription.