Abstract: OBJECTIVE To removal arsenic from Chinese herb extract using resins. METHODS On the basis of static adsorption experiments on the absorption of arsenate by macroporous adsorption resins and anion exchange resins, four kinds of anion exchange resins (D273, D293, D201, D201×7) were selected, and removal rate of arsenic, loss rate of dry ointment yield and removal rate of arsenic/loss rate of dry ointment yield were employed to investigate the removal of arsenic from aqueous extract of Rehmannia Radix. The effect of operating parameters such as flow rate, height to diameter ratio, temperature and concentration of extract on arsenic removal with D293 resin was investigated in multi-factor experiments. Finally, the reusability of D293 resin was evaluated. RESULTS D293 resin had the best arsenic removal ability with about 100% removal rate of arsenic, and the concentration of extract, temperature and flow rate were the main factors that influenced the removal rate of arsenic using D293 in dynamic absorption experiments. D293 resin could be used for 5 times without significant decrease of arsenic removal rate. CONCLUSION Anion exchange resin can be used to remove arsenic from Chinese herb extract.