Abstract: OBJECTIVE To observe the short-term effects and safety of iguratimod on rheumatoid arthritis(RA) complicated with chronic interstitial pneumonia(IP). METHODS The short-term effects and safety of 17 RA patients complicated with chronic IP(from March.2012 to May.2009), whose effects were not satisfied treated by conventional treatment and treated by iguratimod united other drugs, were retrospectively analyzed. RESULTS The ESR, CRP, RF, time of morning stiffness, DAS28 scores of the patients before treated by iguratimod were higher than after treated, the differences of RF was significant(P<0.05), the differences of CRP, ESR, time of morning stiffness, DAS28 score were more significant(P<0.01). The arterial partial oxygen pressure of patients could be improved (P<0.05), the HRCT of lung had no obvious changes after treated; the WBC, HB, PLT had no obvious increase or decrease. Among those 17 patients, there was 1 case (5.9%) with upper abdominal discomfort, 1 case (5.9%) with mildly abnormal liver function, no infection occured. CONCLUSION Iguratimod has exactly short-term effect on RA combined with chronic IP, low incidence of adverse reactions and infection.