Abstract: OBJECTIVE To assess the efficacy of Qishenyiqi drop pill improves angina pectoris symptom and recovers ECG in patients with coronary heart disease(CHD). METHODS All clinical studies of Qishenyiqi drop pill for CHD were searched from Cochrane Library, PubMed, PMC, Medline, EMBASE, CNKI, CBM, VIP and WANFANG DATA. The quality of the included studies was evaluated referring to the cochrane Reviewer′s Handbook 5.1.0, Meta-analysis of Qishenyiqi drop pill for CHD was performed using RevMan 5.2.3 software. Observation index including improvement rate of Angina pectoris symptom and recovery rate of ECG was analyzed and used for quantification. RESULTS Nine studies involving 750 CHD patients were included. The results of meta-analyses showed that Qishenyiqi drop pill combined with conventional treatment significantly improved angina pectoris symptom(RR=1.27, 95%CI: 1.18-1.36, P<0.000 01) and recovered ECG(RR=1.30, 95%CI: 1.18-1.43, P<0.000 01) compared with conventional treatment alone; number needed treat(NNT) was respectively 5.23(95%CI: 4.17-7.14) and 5.00(95%CI: 3.70-7.69), fail-safe number(N_fs0.05) was 138 and 62, respectively. CONCLUSION Qishenyiqi drop pill combined with conventional treatment raise improvement rate of angina pectoris symptom and recovery rate of ECG in patients with CHD. However, due to the existence of publication bias, large sample randomized controlled studies which the methodology design is reasonable will need to be confirmed.