Abstract: OBJECTIVE To summarize the use of single-dose dispense packing machine in the process of drug safety management, and discuss the management. METHODS Single-dose dispense packing machine software system was made full use and the actual situation was combined to strengthen the management of drug safety. RESULTS Single dose-dispense packing machine changed dispensing work mode of oral drugs in inpatient pharmacy. But there were still some problems should be solved. CONCLUSION Single-dose dispense packing machine in combination with standardized management can efficiently improve the pharmacy work quality, promote the change of pharmacists to pharmaceutical technology service.