Abstract: Objective To investigate the effect of salvianolate injection on the levels of serum 8-isoPG, IL-18 and IL-1βin Acute Exacerbated Chronic Obstructive Pulmonary Disease(AECOPD) patients. Methods Sixty patients with acute exacerbated COPD were randomly assigned to the treatment group and the control group. Routine therapies for COPD were given to patients in the control group, while 20mg salvianolate injection was given to those in the treatment group by intravenous dripping, once daily for total 14 days. The changes of 8-isoPG,IL-18, IL-1β,the pulmonary functions and CAT scores were evaluated before treatment and after treatment,which is compared with those of 30 normal controls. Result There are no significant differences in the value of 8-isoPG,IL-18,IL-1β,FEV1/FVC and FEV1% before treatment between two group(P>0.05).Compared with the blank control group, the levels of serum 8-isoPG,IL-18, IL-1βand CAT scores in patient with AECOPD were increased significantly(P <0.01).The levels of serum 8-isoPG,IL-18, IL-1βand CAT scores after treatment was significantly lower than that before treatment(P <0.01);what’s more, the levels of 8-isoPG,IL-18, IL-1βand CAT scoresdecreased more significantly in the treatment group after treatment (P<0.05).The FEV1% and FEV1/FVC were significantly improved after treatment in two group(P<0.01). There are no significant differences between two group in the levels of FEV1% and FEV1/FVC (P＞0.05). Conclusions Salvianolate injection reduce the levels of 8-isoPG,IL-18and IL-1β and improve the clinical symptoms in acute exacerbate COPD patients by inhibiting inflammatory reaction and reduce the oxidative stress.