Abstract: OBJECTIVE To optimize the process for fabrication of Spargaii Rhizoma according to the principle of vacuum steam drug moistening technique through a steam displacement. METHODS To compare the vacuum steam drug moistening technique with the traditional drug moistening method, an orthogonal experiment was designed to evaluate the new technique on multiple factors, using ultraviolet spectrophotometry(UV) to determine the content of total flavonoids in Sparganii Rhizoma, and based on the content of alcohol extract and total flavonoids to find out the best optimization scheme. RESULTS Using the new technique, the Sparganii Rhizoma contained lower moisture and good softening effect while higher content of total flavonoids can be extracted. CONCLUSION Using the vacuum steam drug moistening technique, the medicine can be softened quickly and evenly at lower moisture level. In addition, the content of the total flavonoids in Sparganii Rhizoma is improved. This research provides a reference of the best processing method for Sparganii Rhizoma.