Abstract: OBJECTIVE To determine the concentration of curcumin-meglumin cocrystal by near infrared spectrum. METHODS After purification, standard curve of ultraviolet spectrophotometry was built to evaluate its concentration preliminarily. NIR spectrum was gotten, partial least square method was used to build the determination model, and validate the model. RESULTS The correlation coefficients(R), the root-mean-square error of calibration(RMSEC) of the calibration model for gardenia extract of counter-current gardenoside were 0.999 86 and 0.466. CONCLUSION The established method is simple, rapid and non-destructive for the determination of the concentration of cocrystal.