HIV蛋白酶抑制剂的关键中间体——手性氨基环氧烷合成研究进展

Research Progress of Chiral Amino Epoxide-The Important Intermediate of HIV Protease Inhibitors

摘要: 拟肽类HIV蛋白酶抑制剂是临床治疗艾滋病的主要药物，它们的共性结构片段——(2R, 3S)-3-氨基-4-苯基-2-丁醇从关键中间体手性氨基环氧烷得到，笔者对该中间体的合成研究进行归纳和总结。

Abstract: Peptide analogue HIV protease inhibitors are the main drugs for clinical treatment of AIDS. They have a common structural segment (2R, 3S)-3-amino-4-phenyl-2-butanol, which is synthesized by chiral amino epoxide. In this review, the recent research process in the synthesis methods of this key intermediate is summarized.