Abstract: OBJECTIVE To discuss the role of endothelin receptors in physiological and pathological cardiovascular diseases(CVD), and provide a reference in new drug synthesis and discovery. METHODS According to the correlative reports in recent years, endothelin receptors, especially ETB receptors, and its mechanism and response in the pathophysiology in different organizations were discussed in clinical research. RESULTS Endothelin receptor played an important role in CVD therapy. CONCLUSION Endothelin receptor antagonists have been assumed as potential strategies for the treatment in CVD.