Abstract: OBJECTIVE Wound healing is a common clinical problem, there are various method for treatment. METHODS Reviewed related literatures about the recent research on wound healing. RESULTS Reviewed the mechanism of wound healing and novel topical drug delivery systems potential use in wound healing. CONCLUSION Novel topical drug delivery system has many advantages, such as higher local drug concentration, reducing the side reaction, improving the wound healing, convenient for administration, and improving patient compliance. Novel drug delivery system for the treatment of wound healing has huge market potential.