ICP-MS测定明胶空心胶囊中铅、铬、镉、砷、铜的含量

Determination of Pb, Cr, Cd, As and Cu in Vacant Gelatin Capsules by ICP-MS

摘要: 目的建立明胶空心胶囊中有害重金属元素含量的测定方法，对空心胶囊质量进行控制。方法采用HNO3对明胶空心胶囊进行微波消解制样，利用电感耦合等离子体质谱法(ICP-MS)同时测定样品中5种重金属元素铅、铬、镉、砷、铜的含量。结果部分被测样品中铅、铬、砷有超标现象。该方法的加样回收率为95.4%~104.6%，RSD为1.8%~3.0%。结论本方法操作简便、结果可靠，可用于明胶空心胶囊中重金属元素含量的测定。

Abstract: OBJECTIVE To establish a method to determine heavy metal elements in vacant gelatin capsules so as to control the quality of the samples. METHODS Vacant gelatin capsules were decomposed with HNO3 by microwave digestion and heavy metal elements of Pb, Cr, Cd, As and Cu were determined simultaneously by ICP-MS. RESULTS The analytical results indicated that the content of Pb, Cr, and As in sample were partly beyond the limits. The recovery rates of the method were 95.4%-104.6%, the RSDs were in the range of 1.8%-3.0%. CONCLUSION The method is proved to be accurate, simple and convenient, which can be applied to practical sample analysis.