Abstract: OBJECTIVE To observe the effect of diammonium glycyrrhizinate in treatment of acute cerebral infarction. METHODS All of 120 patients with acute cerebral infarction were randomly divided into treatment group and control group. Patients in the two groups were given conventional neural medical treatment, including anti-platelet, statins, encephalic protection, improving cerebral circulation and controlling blood pressure, and patients in the treatment group were treated with diammonium glycyrrhizinate. NIHSS was used to evaluate defect of neurological function, and the contents of hs-CRP were detected to evaluate the curative effect. RESULTS Compared with control group, NIHSS and the contents of hs-CRP on the 14th, 21th day in treatment group decreased significantly. Clinical effective rate in treatment group(76.7%) was significantly higher than control group(60.0%). CONCLUSION Diammonium glycyrrhizinate could reduce the neurological deficit in patients with cerebral infarction and improve the clinical efficacy. The mechanisms may be related to resultant alleviation of cerebral inflammatory.