电感耦合等离子体质谱法检测明胶空心胶囊中10种元素的含量

Determination of 10 Elements in Vacant Gelatin Capsules by ICP-MS

摘要: 目的建立用电感耦合等离子体质谱(ICP-MS)测定明胶空心胶囊中钒、铬、锰、镍、铜、砷、锶、镉、钡、铅10种元素含量的方法。方法微波消解法处理明胶空心胶囊，用ICP-MS同时检测明胶空心胶囊中10种元素的含量。结果 10种元素的方法检出限范围为0.011~0.203 ng·mL^-1，线性关系良好(r>0.999)，回收率为85%~115%，RSD<10%。结论本方法准确可靠、灵敏便捷，可用于明胶空心胶囊中多种元素的测定。

Abstract: OBJECTIVE To establish a method for the determination of 10 elements such as V, Cr, Mn, Ni, Cu, As, Sr, Cd, Ba and Pb in vacant gelatin capsules by inductively coupled plasma-mass spectrometry(ICP-MS). METHODS The samples were digested by microwave, and ten elements were determined by ICP-MS simultaneously. RESULTS The detection limit ranges of 10 hazard elements were 0.011-0.203 ng·mL^-1, the method had good linear correlation(r>0.999), and the average recoveries were in the range of 85%-115% with RSD less than 10%. CONCLUSION This method is accurate, sensitive, convenient, and can be used to analyse the multi-elements in vacant gelatin capsules