Abstract: OBJECTIVE To observe the effects of Xiaoliu tablet(XLT) on ectopic endometrial, immunity, anti-inflammation and analgesic in mice with endometriosis. METHODS The effect of XLT on immunologic function in mice was studied by transplantation of endometrium. The role of XLT on acute inflammation with xylene-induced mouse ear oedema and abdominal capillary permeability increase caused by glacial acetic acid in mice was observed. Analyesia experiments adopted acetic acid-induced writhing and tail-flick test. RESULTS XLT could reduce the degree of adhesion, area and volume on ectopic focal. Compared with model group, the high dose of XLT group could significantly reduce the volume of ectopic lesions(P<0.05). XLT could reduce the spleen coefficient and promote rising on thymus coefficient, but there were no significant difference (P>0.05). High dose of XLT group obviously inhibited the swelling of mouse pinna induced by xylene, suppressed the increase of mouse blood capillary permeability by acetic acid, significantly depressed the torsion boby of mouse and increased the tail flick latency of 60 minutes(P<0.05). CONCLUSIONS XLT can inhibit adhesion of ectopic endometrial and the enlargement of lesions on endometriosis, high dose group has significant anti-inflammatory and analgesic effect in mice models.