Abstract: OBJECTIVE To discuss the compatibility stability of Doxorubicin Hydrochloride Liposome Injection with Sodium Chloride Injection or Glucose Injection. METHODS After Doxorubicin Hydrochloride Liposome Injection mixed with Sodium Chloride Injection or Glucose Injection, the appearance, pH, particle diameter, content and encapsulation efficiency of the mixture was studied. A HPLC method with Lichrospher C₁₈(250 mm×4.6 mm, 5 μm) was applied to determine the concentration of doxorubicin hydrochloride and the mobile phase was 0.02 mol·L^-1 phosphoric acid solution (0.01 mol·L^-1 sodium dodecyl sulfate)-acetonitrile-methanol(500∶500∶60) at the flow rate of 1.0 mL·min^-1. The column temperature was 30 ℃ and the detective wavelength was 254 nm. Ion-exchange resin method was used to determine the encapsulation efficiency. RESULTS In 6 hours, there was no obvious change in the appearance, pH, particle diameter and content in the mixture of Sodium Chloride Injection. But the encapsulation efficiency decreased 5%. However, there was no obvious change in the mixture of Glucose Injection. CONCLUSION The mixture of Doxorubicin Hydrochloride Liposome Injection and Sodium Chloride Injection was unstability. Doxorubicin Hydrochloride Liposome Injection is compatible with Glucose Injection in clinic.