Abstract: OBJECTIVE To investigate the adverse drug reactions(ADRs) caused by antiepileptic drugs(AEDs), as to promote rational use of drug. METHODS All of 892 ADR cases reported from primary hospital of Zhejiang province in 2008-2012 were collected and analyzed retrospectively. RESULTS The ADRs in male were a little more than that in female, and the proportion was 1.07∶1. The highest incidence rate of ADR caused by convention AEDs was in 41-50 group, while newer AEDs in 21-30 group. Among 892 cases of ADR reports, the top three ADRs were caused by valproic acid(35.09%), carbamazepine(24.55%), and newer AEDs Oxcarbazepine(14.01%), respectively. The main clinical manifestations of ADRs were the damage of the skin or its annexes, the digestive system, central nervous system, and so on. CONCLUSION More attention should be paid to the ADR caused by AEDs in clinic, and the ADR should be monitored and reported regularly to promote rational drug use.