Abstract: OBJECTIVE To study the effects of Celastrus orbiculatu ethanol extract on bone wound healing in rats. METHODS Forty Sprague-Dawley rats were randomly divided into 5 groups: pseudo surgery group, model group, drug-positive group, Celastrus orbiculatu ethanol extract high-dose and low-dose groups with 8 rats in each group. After surgical trauma femur, water or drugs were administrated to rats according to dose dosage for 45 days. The blood serum calcium, phosphorus, alkaline phosphatase contents were examined. The femur callus was took an X-ray photograph. Femur callus bone mineral density was calculated by computer software. The femur callus flexural strength was determined. RESULTS The blood serum calcium, phosphorus, alkaline phosphatase contents, the femur callus bone mineral density and the femur callus flexural strength were increased in the Celastrus orbiculatu ethanol extract high dose group and positive-drug group, which compared with the model group was statistically significantly different(P<0.05). CONCLUSION Celastrus orbiculatu ethanol extract can effectively promote the rat bone wound healing.