Abstract: OBJECTIVE To study parecoxib thyroid cancer functional neck lymph node dissection in patients with postoperative analgesic effects and psychological state. METHODS According to the American Society of Anesthesiologists (ASA) classification, ASA I-II level elective anesthesia thyroid cancer, the functional cervical lymph node dissection in 34 patients were randomly divided into parecoxib sodium group and control group. Parecoxib group after operation immediately, 12, 24, 36, respectively was intravenously given parecoxib sodium 40 mg; 5 mL saline was administered at each time point in control group. After 6, 12, 24 and 48 h, mental state of the visual analog pain score(VAS) was recorded. The psychology self-rating scale before and after surgery were evaluated. RESULTS The parecoxib group VAS in postoperative 6, 12, 24 h, were significantly lower than the control group(P<0.05); parecoxib sodium group after the psychology assessment indicators were significantly better than the control group(P<0.05). CONCLUSION Postoperative analgesic effect of parecoxib can improve thyroid cancer functional neck lymph node dissection in patients with postoperative psychological stress.