Abstract: OBJECTIVE To establish an efficient method for isolating and purifying anthocyanins from purple sweet potato, provide a theoretical basis for its industrial development. METHODS The static adsorption and desorption tests had been done to screen for the optimum macroporous resin and condition for purifying anthocyanins extracted from salt-tolerant purple sweet potato Z103, the dynamic adsorption and desorption properties of the resins were studied additionally. RESULTS The macroporous resin HPD-300 was the most favorable adsorbent. The time of absorption and desorption equilibrium was 6-8 h and 1-2 h, respectively. The absorption capacity of HPD-300 was 33.67 mg·g^-1. The optimized parameters of dynamic adsorption resolve were 1.0 mL·min^-1 current velocity, initial concentration 0.3 mg·mL^-1, with a flow rate of 1.0 mL·min^-1, and sample volume of 145 mL, the adsorption content was 13.82 mg·g^-1(resin), while 80% ethanol with pH 1.0 as eluent, 3 BV, flow rate at 1.0 mL·min^-1, the desorption rate was 92.01%. The content of purified anthocyanins was 181.58 mg·g^-1, with a increase of 13.18 times compared with before purification, the color value of purified anthocyanins was 142.63, with a increase of 11.01 times. CONCLUSION The optimized process has practical and reference value.