Abstract: OBJECTIVE To study the role of ibuprofen joint Xiongma decoction in the migraine model mice of low 5-HT with local cerebral vasospasm induced by reserpine. METHODS By giving hypodermic injection of 10 mg·kg^-1 reserpine for 14 days, copied migraine model was established. On the 14th day after ether anesthesia in mice, puncture cerebral cortex to inject blood clots(2 μL per mice) was conducted, to observe the effect of ibuprofen joint Xiongma decoction on weight, coagulation time, 5-HT and 5-HIAA level in plasma. RESULTS Ibuprofen joint Xiongma decoction could increase body weight, prolong coagulation time, prevent excessive decrease in 5-HT and improve the content of 5-HIAA. Compared with the model group, the difference was significant(P<0.01). CONCLUSION Ibuprofen joint Xiongma decoction is effective on migraine mice induced by reserpine.