Abstract: OBJECTIVE To undertake a contrastive study on safety and pharmacodynamics of sodium aescinat powder injection and micro-emulsion injection. METHODS New Zealand rabbits were chosen as experimental animals for hemolysis and vascular stimulation tests, and its safety for therapy was probed. Investigate the inhibitory effect on xylene-induced mouse ear edema and capillary permeability-increasing, and a preliminary pharmacodynamics evaluation was made. RESULTS Both of sodium aescinat powder injection and micro-emulsion injection had slight hemolysis and stimulation, there was no evident difference between the two groups; both groups of high dose and low dose sodium aescinat powder injection and micro-emulsion injection had remarkable restrictive effect on mouse ear edema and capillary permeability-increasing, the antagonistic action of micro-emulsion injection was more apparent. CONCLUSION Both of sodium aescinat powder injection and micro-emulsion injection have a certain intravenous security risk, and they also have significant anti-inflammatory effects, the anti-inflammatory effects of sodium aescinat micro-emulsion injection is more apparent.