Abstract: OBJECTIVE To explore the effect of baicalein combined with paclitaxel on human lung carcinoma cell line QG-56. METHODS QG-56 cells were treated with baicalein, paclitaxel alone or their combination, with the untreated cells used as control. After 24, 48, 72, 96 hours of treatment, the cell growth condition was observed by invert microscope and inhibitation rate was studied by MTT assay. The apoptosis was analyzed by flow cytometry. RESULTS The cell population decreased and shape, size changed after treating with different concentration of experimental groups. Baicalein and paclitaxel used alone or in combination both inhibited the proliferation of QG-56 cells. The inhibition ratio of their combination was more higher(P<0.05), and a synergistic effect of the two agents was noted in their combined action(P<0.05). Combined treatment of the cells resulted in significantly higher apoptsis rate than that alone(P<0.05). CONCLUSION Baicalein can significantly inhibit QG-56 cell growth. It can act synergistically with paclitaxel to inhibit the tumor proliferation of QG-56 cells．A synergistic effect is observed between them.