罗红霉素晶型分析及与溶解速率、溶出度的关系

Relationship of Roxithromycin Crystal Types, Dissolution Rates and Dissolution

摘要: 目的对罗红霉素的晶型进行分析，并探讨不同晶型对罗红霉素溶解速率、溶出度的影响。方法晶型分析采用X射线粉末衍射法和红外光谱法，溶解速率和溶出度测定采用转篮法，转速为100 r·min^-1。结果 3种罗红霉素的结晶为3种不同的晶型，不同晶型的罗红霉素溶解速率和溶出度有一定差异。结论为罗红霉素用药的有效性提供了科学依据。

Abstract: OBJECTIVE To study the crystal types of roxithromycin, and the relationship of roxithromycin crystal types and its dissolution rate and dissolution. METHODS X-ray powder diffraction and infrared spectroscopy were used in the analysis of crystal types. The dissolutive apparatus was used with 100 r·min^-1. RESULTS The result showed that three crystals of roxithromycin were different crystal types, and the dissolution rates and dissolutions of different crystal types had some differences. CONCLUSION The study provids a scientific basis for the effectiveness of roxithromycin.