苦杏仁苷凝胶制备工艺的研究
Preparation of Amygdalin Gel
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摘要: 目的 筛选苦杏仁苷凝胶基质，确定制备工艺。方法 采用体外经皮渗透法，使用透皮扩散试验仪，用HPLC测定接受液中苦杏仁苷含量，以透皮速率为考察指标，通过正交试验筛选基质。结果 苦杏仁苷凝胶剂的优化处方组成为1%卡波姆、15%甘油、10%丙二醇、0.5%三乙醇胺。结论 该凝胶制备工艺简单，透皮效果好。Abstract: OBJECTIVE To screen amygdalin gel matrix to determine the preparation process. METHODS Using transdermal diffusion test instrument in vitro, the content of amygdalin in the received solution was determined by HPLC. Steady-state penetration rate was served as investigation indexes by orthogonal test. RESULTS Matrix dosage included 1%carbomer, 15% glycerin, 10%propylene glycol, 0.5% triethanolamine. CONCLUSION The preparation is simple, and the transdermal effect is good.
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