Abstract: OBJECTIVE To formulate an evidence-based treatment plan for a patient with bronchiectasis infected the mucoid Pseudomonas aeruginosa. METHODS A search was conducted in the Cochrane Library, PubMed, CNKI and Wanfang Data to obtain and evaluate the relevant systematic reviews, meta-analysis and randomized controlled and finally to apply the best evidence in clinical practice. RESULTS The pathogens once protected by the biofilm could be cleared by the low dose of azithromycin associated with anti-Pseudomonas aeruginosa antimicrobial agents. The results was good after the the plan was applied to the patient. CONCLUSION To formulate an evidence-based treament plan can improve the patient curative effect.