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    丙泊酚的配伍研究

    Compatibility of Propofol Emulsion

      摘要
    • 摘要: 目的 考察室温下6 h内，丙泊酚乳剂与利多卡因注射液和/或地塞米松注射液配伍后的稳定性。方法 采用离心分光光度法、苏丹染色实验、电导率测定以及混合液pH值和激光粒度分析等方法来考察丙泊酚(A组)、丙泊酚与利多卡因9∶1混合(B组)、丙泊酚与利多卡因4∶1混合(C组)、丙泊酚与利多卡因及0.5%地塞米松以3∶1∶1的比例混合(D组)的稳定性。结果 室温下6 h内，B、C、D组与A组比较，稳定常数(Ke)值明显增高(P<0.05)。各组未见分层和颜色变化。B组与A组比较，各时点pH值明显降低，具有显著性差异(P<0.05)，D组与B组比较，各时点pH值明显升高(P<0.05)。电导率值为A组 

      Abstract: OBJECTIVE To investigate the compatibility of propofol emulsion combined with lidocaine injection and/or dexamethasone injection. METHODS Centrifugal spectrophotometry, Sudan test, conductivity measuring, pH and laser particle size analysis were used to observe the stability of propofol(group A), propofol and lidocaine mixed by 9∶1(group B), propofol and lidocaine mixed by 4∶1(group C), propofol and lidocaine and dexamethasone mixed by 3∶1∶1(group D) within 6 hours under room temperature. RESULTS The Ke of group B, C, D were significantly increased compared with group A, (P<0.05). Each group showed no stratification and color change. The pH of group B was decreased compared with group A at each time(P<0.05). The conductivity value of group A 

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