Abstract: OBJECTIVE To study the effect of Xueshuantong injection on plasm biomarker including NSE, S100B, MBP and GFAP concentrations in patients with traumatic cerebral infarction, and thus to investigate its effect of promoting the recovery of neural function. METHODS Eighty patients with traumatic cerebral infarction were randomly divided into control group(n=40) and treatment group(n=40). Control group obtained ordinary therapy, and treatment group obtained additional Xueshuantong injection. Pre-treatment and after 1, 3, 7, and 14 d treatment, NSE, S100B, MBP and GFAP concentraions in plasma were determined. The effects of Xueshuantong injection on these plasma biomarker were investigated. RESULTS Pre-treatment, there were no statistically significant differences of NSE, S100B, MBP and GFAP concentraions in the plasma between treatment group and control groups(all P>0.05). After treatment, compared with control group, Xueshuantong injection could markedly diminish NSE, S100B, MBP and GFAP concentraions in plasma of patients with traumatic cerebral infarction (all P<0.01). CONCLUSION Xueshuantong injection can markedly inhibit the enhancement of NSE, S100B, MBP and GFAP concentraions in plasma after traumatic cerebral infarction, and possesses obvious cerebral protective effect.