Abstract: OBJECTIVE To find out the cause of hypopituitarism induced by ATG in the process of intensive immunosuppressive therapy (IST) for severe aplastic anemia, and to prevent related complications. METHODS A case of hypopituitarism induced by ATG was chosen, which clinical physician participated in the whole treatment and literatures were reviewed. RESULTS ATG can induce hypopituitarism, which should bring enough attentions in clinical. CONCLUSION In the clinical diagnosis and treatment of severe aplastic anemia, we should pay more attention to the potential complications, so as to reduce the risk of treatment, improve the outcome of treatment.